1. Viscusi ER, Martin G, Hartrick CT, Singla N, Manvelian G; for
EREM Study Group. Forty-eight hours of postoperative pain relief
after total hip arthroplasty with a novel, extended-release epidural
morphine formulation. Anesthesiology . 2005;102(5):1014-1022.

2. Martin G, Hartmannsgruber M, Riley E, Manvelian G. Single-dose
extended-release epidural morphine for pain after hip arthroplasty.
J Opioid Manag . 2006;2(4):209-218.

3. Carvalho B, Riley E, Cohen SE, et al; for DepoDur Study Group.
Single-dose, sustained-release epidural morphine in the management
of postoperative pain after elective cesarean delivery: results of a
multicenter randomized controlled study. Anesth Analg . 2005;100(4):

4. Gambling D, Hughes T, Martin G, Horton W, Manvelian G; for
Single-Dose EREM Study Group. A comparison of DepoDur™, a novel,
single-dose extended-release epidural morphine, with standard epidural
morphine for pain relief after lower abdominal surgery. Anesth Analg .

5. Carvalho B, Roland LM, Chu LF, et al. Single-dose, extended-release
epidural morphine (DepoDur TM ) compared to conventional epidural
morphine for post-cesarean pain. Anesth Analg . 2007;105(1):176-183.

6. Geerts WH, Bergqvist D, Pineo GF, et al. Prevention of venous
thromboembolism: American College of Chest Physicians
evidence-based clinical practice guidelines (8th ed). Chest .
2008;133(6 suppl):381S-453S.

7. American Society of Regional Anesthesia and Pain Medicine.
Regional anesthesia in the anticoagulated patient: defining the
risks (Second Consensus Conference on Neuraxial Anesthesia and
Anticoagulation). ASRA Web site. Accessed December 30, 2008.

8. Crews JC. Epidural opioid analgesia. Crit Care Clin. 1990;6(2):315-342.

9. Hartrick CT, Manvelian G. Sustained release epidural morphine
(DepoDur TM ): a review. Today’s Therapeutic Trends . 2004;22(3):167-180.

10. Pegues DA, Carr DB, Hopkins CC. Infectious complications associated
with temporary epidural catheters. Clin Infect Dis . 1994;19:970-972.

11. DuPen SL, Peterson DG, Williams A, Bogosian AJ. Infection during chronic
epidural catheterization: diagnosis and treatment. Anesthesiology .

12. Viscusi ER. Patient-controlled drug delivery for acute postoperative pain
management: a review of current and emerging technologies. Reg Anesth
Pain Med
. 2008;33(2):146-158.

13. Data on file. EKR Therapeutics, Inc.

14. DepoDur [package insert]. Bedminster, NJ: EKR Therapeutics, Inc.; 2007.

15. American Society of Anesthesiologists Task Force on Neuraxial Opioids.
Practice guidelines for the prevention, detection, and management of
respiratory depression associated with neuraxial opioid administration.
Anesthesiology . 2009;110(2):218-230.

16. Keck S, Glennon C, Ginsberg B. DepoDur ® extended-release epidural
morphine: reshaping postoperative care: what perioperative nurses need
to know. Orthop Nurs . 2007;26(2):86-93.

17. Howell SB. Clinical applications of a novel sustained-release injectable drug delivery system: DepoFoam TM technology. Cancer J . 2001;7(3):219-227.

Important Safety Information

DepoDur is not intended for intrathecal, intravenous, or intramuscular administration. Administration of DepoDur into the thoracic epidural space or higher has not been evaluated and therefore is not recommended. The majority of adverse events were typical opioid-related side effects and would be expected in the surgical populations studied. No statistically significant differences between treatment groups with respect to nausea, pruritus, sedation scores, vomiting episodes, or urinary retention.

More information on safety page.

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