DepoDur: Overview

Extended Postoperative
Pain Relief After
Major Surgery

Superior pain relief for up to 48 hours
with a single epidural injection of extended-
release morphine, compared to IV PCA 1, 2, *
or conventional epidural MS injection 3-5

Efficacy shown by multiple measures
in patients undergoing various
surgical procedures 1-5


No Indwelling
Epidural Catheter

Postoperative anticoagulation
of appropriate patients
that avoids the limitations of indwelling catheter use 6,7

Premits VTE * prophylaxis without delay

Avoidance of complications and restrictions
related to epidural catheters

Infection 8-11
Epidural hematoma 8,9,12
Catheter kinking, dislodgement, migration 8,9,12
Impaired patient mobility 12

DepoDur is contraindicated in patients with known hypersensitivity to morphine or the product components and those patients with respiratory depression, acute or severe bronchial asthma, upper airway obstruction; those who have or are suspected of having paralytic ileus, head injury, or increased intracranial pressure; and those who are in circulatory shock. Any contraindications for an epidural injection preclude use of DepoDur.

*Intravenous patient-controlled analgesia.
† Morphine sulfate.
‡ Venous thromboembolism.

Important Safety Information

DepoDur is not intended for intrathecal, intravenous, or intramuscular administration. Administration of DepoDur into the thoracic epidural space or higher has not been evaluated and therefore is not recommended. The majority of adverse events were typical opioid-related side effects and would be expected in the surgical populations studied. No statistically significant differences between treatment groups with respect to nausea, pruritus, sedation scores, vomiting episodes, or urinary retention.

More information on safety page.

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