DepoDur: How It Works

Morphine sulfate is enclosed in
microscopic lipid-based particles 14,17
The particles gradually erode, releasing
morphine over a period of time 14,17
Onset of action: about 3 hours 2,13
Duration of action: up to 48 hours 14
Monitoring should continue for the duration of the therapeutic effect; therefore, patients taking DepoDur
should be monitored for 48 hours

Important Safety Information

DepoDur is not intended for intrathecal, intravenous, or intramuscular administration. Administration of DepoDur into the thoracic epidural space or higher has not been evaluated and therefore is not recommended. The majority of adverse events were typical opioid-related side effects and would be expected in the surgical populations studied. No statistically significant differences between treatment groups with respect to nausea, pruritus, sedation scores, vomiting episodes, or urinary retention.

More information on safety page.

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